Publications & Research

Building upon his work developing foundational pharmacogenetic assays for antifolate therapies, Brian Meshkin explores the relationship between dietary folate metabolism, nutritional genetics, and folic acid supplementation. The publication highlights the growing intersection between pharmacogenetics and personalized nutrition.

This publication examines the complex genetic basis of ADHD, proposing that the disorder is highly polygenic and influenced by numerous genes involved in neurotransmitter metabolism, transport, and receptor function. The paper challenged conventional views of ADHD and contributed to the understanding of its biological foundations.

Researchers from Proove evaluated the impact of incorporating genetic testing into the management of chronic pain. The study demonstrated how genetic information could assist clinicians in developing more individualized treatment strategies for patients experiencing chronic non-cancer pain.

This validation study evaluated the Proove Opioid Risk algorithm, which integrates genetic and clinical variables to estimate an individual's risk for opioid use disorder. The publication provides evidence supporting the algorithm's application within precision medicine and opioid risk assessment.

This clinical case report describes the application of precision medicine in the treatment of a patient experiencing unresolved pain following orthopedic surgery. The report highlights how genetic testing informed clinical decision-making and personalized pain management.

This prospective clinical study evaluated the real-world utility of the proprietary Proove predictive algorithm for opioid use disorder risk stratification. The findings support the use of integrated genetic and clinical data to improve individualized patient risk assessment.

This publication outlines how pharmacogenetic testing can be incorporated into evidence-based treatment guidelines for injured workers suffering from chronic pain. The recommendations contributed to the broader discussion surrounding precision medicine in workers' compensation and informed later updates to clinical practice guidelines.

This study evaluated the performance of the Proove Opioid Risk algorithm in an addiction treatment setting. The researchers reported strong predictive performance, supporting the algorithm's application for identifying individuals at elevated risk of opioid misuse within clinical addiction medicine.