Brian Meshkin
Brian Meshkin
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Ink (Media) & Think (Blog)

Ink (RECENT - 2023 & 2024)

A Predictive Healthcare Visionary Is Optimistic About Solving Opioid Addiction And Chronic Pain

A Predictive Healthcare Visionary Is Optimistic About Solving Opioid Addiction And Chronic Pain

A Predictive Healthcare Visionary Is Optimistic About Solving Opioid Addiction And Chronic Pain

Zenger News

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America Finds Its Partner in Combating the Opioid Crisis and Chronic Pain with Outcomeus

A Predictive Healthcare Visionary Is Optimistic About Solving Opioid Addiction And Chronic Pain

A Predictive Healthcare Visionary Is Optimistic About Solving Opioid Addiction And Chronic Pain

Newsfile Corp

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How Predictive Healthcare Can Improve African American Women’s Experience

A Predictive Healthcare Visionary Is Optimistic About Solving Opioid Addiction And Chronic Pain

Brian Meshkin Sues DOJ to Stop Abuses of Power Which Destroyed His Business, Seeks Restitution

Kalina Bryant

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Brian Meshkin Sues DOJ to Stop Abuses of Power Which Destroyed His Business, Seeks Restitution

Brian Meshkin Sues DOJ to Stop Abuses of Power Which Destroyed His Business, Seeks Restitution

Brian Meshkin Sues DOJ to Stop Abuses of Power Which Destroyed His Business, Seeks Restitution

Newsfile Corp

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Innovator Brian Meshkin and Leading Litigation Law Firm Sue Federal Government

Brian Meshkin Sues DOJ to Stop Abuses of Power Which Destroyed His Business, Seeks Restitution

Innovator Brian Meshkin and Leading Litigation Law Firm Sue Federal Government

Newsfile Corp

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Proove Founder Gets Federal Charges Dismissed. Truth Prevails, Meshkin Says

Brian Meshkin Sues DOJ to Stop Abuses of Power Which Destroyed His Business, Seeks Restitution

Innovator Brian Meshkin and Leading Litigation Law Firm Sue Federal Government

By Peter J. Brennan, Editor

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Ink (Pre-2023)

Former Proove CEO Meshkin Starts Venture Fund: Plans lawsuits to fight “false allegations”

Former Proove CEO Meshkin Starts Venture Fund: Plans lawsuits to fight “false allegations”

Former Proove CEO Meshkin Starts Venture Fund: Plans lawsuits to fight “false allegations”

By Sherry Hseih, Healthcare Editor


Meshkin’s venture fund is a “social entrepreneurship accelerator that is helping profound social problems.” Profound Ventures plans to make seed investments in the five- to low six-digits, starting with healthcare opportunities. The current portfolio includes technologies to help people age at home.

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Earthly Angels: In the season of comfort and joy, celebrate those who comfort in despair

Former Proove CEO Meshkin Starts Venture Fund: Plans lawsuits to fight “false allegations”

Former Proove CEO Meshkin Starts Venture Fund: Plans lawsuits to fight “false allegations”

By Mary Corey, Reporter


He has rallied… to many causes, including fighting prejudice, hunger, homelessness, domestic violence and cancer… Brian's efforts have not gone unnoticed. This year he received a community service award from the United Way of Central Maryland and was named Maryland's young volunteer of the year by the Veterans of Foreign Wars.

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He Felt Your Pain

Former Proove CEO Meshkin Starts Venture Fund: Plans lawsuits to fight “false allegations”

The fervor of a young campaigner: Brian Meshkin, believes the System works.

By Vita Reed, Reporter


Brian Meshkin sought a way to help doctors make better decisions in the specialty of pain management, acting on the desire in 2009 when he created Irvine-based Proove Biosciences Inc. Meshkin, Proove’s founder and chief executive, was one of five winners honored by the Business Journal at its 15th annual Excellence in Entrepreneurship Awards at a March 10 luncheon at Hotel Irvine

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The fervor of a young campaigner: Brian Meshkin, believes the System works.

The fervor of a young campaigner: Brian Meshkin, believes the System works.

The fervor of a young campaigner: Brian Meshkin, believes the System works.

By David Folkenflik, Now an NPR Correspondent


There's a simple answer: Above all, Meshkin appears to be a young man who believes fervently that The System works. His brief life seems to prove the cliches: If you play by the rules, work hard, keep your head down and fight for what you believe, you'll succeed. While canny enough to work the system, it's little wonder that Meshkin believes in it.

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Why Shouldn't Kids Lead the Charge on Gun Safety?

The fervor of a young campaigner: Brian Meshkin, believes the System works.

Why Shouldn't Kids Lead the Charge on Gun Safety?

By Kathleen Bachynski, Angela Turi, and Alison Bateman-House


Eighth grader Brian Meshkin, who was on the scene of the crash that killed Kelley, led the students’ committee on bike helmet legislation. The group prepared surveys to document the need for a law, called newspapers and television stations to seek editorial support, and testified during a Howard County Council meeting.

As a result of their activism, the local council approved the new ordinance on May 7, 1990. 

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Micro-Agility CXO Series

The fervor of a young campaigner: Brian Meshkin, believes the System works.

Why Shouldn't Kids Lead the Charge on Gun Safety?

By Sajid Khan


SK: What advice would you offer to our readers who aspire to follow in your footsteps?

Brian: When starting a business, don’t try to do it based on a hypothesis or  “if…then” statement. So many entrepreneurs say, “if” I can do this or  that, “then” I will be able to do this or that. Such a hypothesis makes  your business an experiment subject to conditions. Success has never  been a condition, it has been a destination for me. Eliminate the “ifs”  and focus on how to incrementally do the “thens”. By doing this, you  won’t wait to do what is necessary to succeed.

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Doctor in the Dugout - Hoag Medicine (podcast)

Doctor in the Dugout - Hoag Medicine (podcast)

Doctor in the Dugout - Hoag Medicine (podcast)

Brian Meshkin is interviewed by Dr. Alan Beyer from Hoag Orthopedic Institute, a client of Proove Biosciences

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Power to Be in Biotechnology

Doctor in the Dugout - Hoag Medicine (podcast)

Doctor in the Dugout - Hoag Medicine (podcast)

Back in 2008, the San Diego Magazine chose Brian as an Honorable Mention in the Powers to Be in Biotechnology.

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Critical Mass Radio (podcast)

Doctor in the Dugout - Hoag Medicine (podcast)

Critical Mass Radio (podcast)

Brian Meshkin, President and CEO of Proove BioSciences joined  Critical Mass Radio Show to how his firm is changing the future of  medicine. 

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Blog Talk Radio (podcast)

The genetic test that can help fix America’s opioid painkiller addiction

Critical Mass Radio (podcast)

A social entrepreneur with innovative solutions to society’s most  pressing social problems, Brian is an ambitious and persistent leader  who lays out Proove’s vision and continues to lead the Company with  dramatic revenue growth, disruptive technological innovations, a robust  pipeline of new proprietary tests, and financial profitability.

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The genetic test that can help fix America’s opioid painkiller addiction

The genetic test that can help fix America’s opioid painkiller addiction

The genetic test that can help fix America’s opioid painkiller addiction

By Jeniece Pettitt


Brian Meshkin founded Irvine, California-based Proove Biosciences in   2009. The company developed a portfolio of tests that can  determine  someone’s pain profile and tolerance to different pain  medications to  give doctors more information before prescribing  medication.

Read and Watch Here

A medical test that aims to wean America off painkillers

The genetic test that can help fix America’s opioid painkiller addiction

The genetic test that can help fix America’s opioid painkiller addiction

By Dina Gusovsky


Sixty  percent of the score a patient receives is based on testing  for  genetic markets associated with addiction, of which there are   several, including COMT, dopamine receptors and the  opioid MU1 receptor  gene.

 The other 40 percent of the addiction-risk score  comes from  personal factors: age, personal medical history, previous   substance abuse and any history of depression (due to its links  to drug  use). 

Read and Watch Here

Genetic Test Aims To Identify Those Predisposed To Opioid Addiction

Meshkin reflects on school board tenure, says panel reflected 'dysfunction'

Meshkin reflects on school board tenure, says panel reflected 'dysfunction'

An Irvine biotech company is hoping to take on the nation’s opioid  epidemic with a genetic test it says can identify patients who are  predisposed to getting addicted to painkillers.

The problem is clear: Nearly 2 million people were found to be  addicted to pain medication and nearly 19,000 people died from taking  pain medication in 2014, according to the American Society of Addiction  Medicine.

Watch the Report Here

Meshkin reflects on school board tenure, says panel reflected 'dysfunction'

Meshkin reflects on school board tenure, says panel reflected 'dysfunction'

Meshkin reflects on school board tenure, says panel reflected 'dysfunction'

By Joe Burris


Meshkin advocated programs and practices implemented by the school  system during his tenure, including digital education, processes to  streamline the district's operations and a task force for student mental  health. He also took part in board meetings via digital conference and  said he engaged in efforts to establish transport for students taking  evening and weekend classes.

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Howard school board member Meshkin not seeking re-election

Meshkin reflects on school board tenure, says panel reflected 'dysfunction'

Howard school board member Meshkin not seeking re-election

By Sara Toth


Meshkin  cited the growing success of his business — Proove Biosciences — as  well as increasing time constraints therein, and a desire to spend more  time with his family as reasons for his decision. "I  do this with a heavy heart," he said. "I love serving my community. ...  But there is a time and a season for everything, and at this stage in  my life with a company based in California that is growing by leaps and  bounds, and the precious time I am missing with my children, I must  place the needs of my family first."

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David Beats Goliath: MESHKIN VINDICATED, ALL CHARGES DISMISS

OC Business Journal Covers Dismissal of All False Allegations

OC Business Journal Covers Dismissal of All False Allegations

OC Business Journal Covers Dismissal of All False Allegations

The allegations "resulted in the destruction of Proove Biosciences and the smearing of many reputations," Meshkin said. 

Read the OC Business Journal Article

OC Register Covers Dismissal of All False Allegations

OC Business Journal Covers Dismissal of All False Allegations

OC Business Journal Covers Dismissal of All False Allegations

The U.S. Attorney’s Office said in a court motion last week that it dismissed the case against Brian Javaade Meshkin, 46, “in the interests of justice.” The Ladera Ranch man, founder of Proove Biosciences Inc., was indicted in 2021, along with 8 other defendants on charges of conspiracy and receiving and making illegal payments.

Read the OC Register Article

Proove Biosciences CEO Exonerated in PGx Test Kickback Case

OC Business Journal Covers Dismissal of All False Allegations

Proove Biosciences CEO Exonerated in PGx Test Kickback Case

A federal judge in California has dismissed charges against the CEO of embattled genetic testing company Proove Biosciences who along with other individuals had been accused of paying physicians at least $3.5 million in kickbacks.


In a statement published Monday, Proove said, "These false allegations levied against Meshkin and Proove cause

A federal judge in California has dismissed charges against the CEO of embattled genetic testing company Proove Biosciences who along with other individuals had been accused of paying physicians at least $3.5 million in kickbacks.


In a statement published Monday, Proove said, "These false allegations levied against Meshkin and Proove caused tremendous harm, as they have been widely disseminated publicly and in the media. With this dismissal, the defendants are vindicated, and this flawed investigation has been thoroughly discredited."

Read the Genome Web Article

U.S. Government Soundly Defeated In Alleged Kickback Scheme

San Diego feds dismiss fraud case amid accusations over prosecutorial missteps

Proove Biosciences CEO Exonerated in PGx Test Kickback Case

By Kim Delmonico

The United States government was soundly defeated and forced to ask a Federal Judge to dismiss all charges against an innovative young California company and the clinics it serves.

The judge for the United States District Court in the Central District of California has issued an order granting the United States Government’s

By Kim Delmonico

The United States government was soundly defeated and forced to ask a Federal Judge to dismiss all charges against an innovative young California company and the clinics it serves.

The judge for the United States District Court in the Central District of California has issued an order granting the United States Government’s motion to dismiss all charges in a case involving physicians and other employees from Physical Medical Associates, Ltd., National Spine and Pain Center, LLC, and Proove Biosciences, Inc.


Proove is an Irvine, California-based biosciences company that specializes in the genetic testing of pain patients. According to the company, its “proprietary effective technology” includes “genetic tests and predictive software algorithms in its CLIA-certified, CAP-accredited state-of-the-art laboratory that helped doctors objectively assess pain, predict who would misuse opioids with up to 96.7% accuracy, and provide treatment insights which resulted in 50% pain reduction within 30 days of treatment changes, saving Medicare over $70 million annually.”

Read the Orthopedics in Review Article

Pain News Network Covers Exoneration

San Diego feds dismiss fraud case amid accusations over prosecutorial missteps

San Diego feds dismiss fraud case amid accusations over prosecutorial missteps

The U.S. Department of Justice has quietly dropped criminal charges against the founder and CEO of Proove Biosciences, a genetic testing company based in California that was accused of paying physicians over $3.5 million in illegal kickbacks. A judge dismissed the case against Brian Meshkin and five other defendants last month “in the int

The U.S. Department of Justice has quietly dropped criminal charges against the founder and CEO of Proove Biosciences, a genetic testing company based in California that was accused of paying physicians over $3.5 million in illegal kickbacks. A judge dismissed the case against Brian Meshkin and five other defendants last month “in the interests of justice” after federal prosecutors declined to move forward with the case. 

Read the Pain News Network Article

San Diego feds dismiss fraud case amid accusations over prosecutorial missteps

San Diego feds dismiss fraud case amid accusations over prosecutorial missteps

San Diego feds dismiss fraud case amid accusations over prosecutorial missteps

Jason de Bretteville, defense attorney for the lead defendant, Proove CEO Brian Meshkin, said the government attorneys never disclosed specifically why they sought a dismissal, but he speculated it was based on the case’s merits and “emerging issues relating to potential government misconduct.”


Meshkin said the decision to dismiss the case

Jason de Bretteville, defense attorney for the lead defendant, Proove CEO Brian Meshkin, said the government attorneys never disclosed specifically why they sought a dismissal, but he speculated it was based on the case’s merits and “emerging issues relating to potential government misconduct.”


Meshkin said the decision to dismiss the case was vindication for him and his co-defendants.

“There has been so much injustice over the past (six) years that it is wonderful to see truth prevail,” Meshkin wrote in a statement he sent to the Union-Tribune. “Ultimately, the facts spoke for themselves.”


Meshkin called the investigation a “foolish” waste of millions of taxpayer dollars that resulted from “misinformation spread by a handful of disgruntled ex-employees and contractors, spread by the media, and blindly adopted by some in the Southern District of California office of the U.S. Attorney and the FBI.”


Read the San Diego Union Tribune Article

Proove Biosciences CEO Exonerated in PGx Test Kickback Case

Proove Biosciences CEO Exonerated in PGx Test Kickback Case

Proove Biosciences CEO Exonerated in PGx Test Kickback Case

A federal judge in California has dismissed charges against the CEO of embattled genetic testing company Proove Biosciences.

Read 360Dx Article

Personal Statement from Brian Meshkin on the Vindication

Proove Biosciences CEO Exonerated in PGx Test Kickback Case

Proove Biosciences CEO Exonerated in PGx Test Kickback Case

“There has been so much injustice over the past 6 years that it is wonderful to see truth prevail.  I am excited to have the opportunity to set the record straight and to move forward from here with my head held high,”

Read Brian Meshkin's Personal Statement

My Blog

Video about Proove Biosciences from the SmartCEO Award

3 Time Award Winner, SmartCEO Magazine

Video from the 2016 OCTANE-OC TECH ALLIANCE Award

The year Brian won the Emerging Technology Company CEO of the Year (2016)

Video from PRESS Conference with fmr Congresswoman Mary Bono

Press conference with former Congresswoman Mary Bono and world leading expert in pain genetics, Dr. Luda Diatchenko, discussing Proove's award-winning data being presented at the American Academy of Pain Medicine annual meeting in Palm Springs 

Video from brian's keynote address at the 2019 10x medical d

Proove Biosciences Downfall: What Happened? | 10x Medical Conference

Video from brian's keynote address at the 2022 10x Meeting

Proove Biosciences Redeemed: Back and Better Than Ever with Brian Meshkin at 10x Device Conference 

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